Abcam, ab236412, Anti-SERPINB13 antibody [OTI2B6]

Size: 100µL
Mouse Monoclonal SERPINB13 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human SERPINB13.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:OTI2B6,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human SERPINB13.Q9UIV8

Product details:
Clone OTI2B6 (formerly 2B6).

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Purification notes-Purified from cell culture supernatant., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SERPINB13 also known as Headpin is a member of the serine protease inhibitor family. This protein is known for its role in inhibiting protease activities to protect tissues from excessive proteolytic damage. SERPINB13 has a molecular mass of approximately 44 kDa. Expression is most noted in the epithelial tissues of the tongue and esophagus but it also appears in other stratified squamous epithelia. The protein performs its function intracellularly modifying local protease environments.
Biological function summary
SERPINB13 regulates proteolytic processes by forming stable complexes with target proteases. It acts as an inhibitor to prevent unwanted protease activity keeping cellular proteolysis balanced. Although not part of any protease complexes directly SERPINB13 aligns functionally with other members of the serpin family that regulate protease activity across different tissues. This regulation is important especially in epithelial tissue where frequent renewal occurs.
Pathways
SERPINB13 interacts with cellular mechanisms such as the extracellular matrix (ECM) degradation pathway. In this context it acts alongside proteins like matrix metalloproteinases (MMPs) that require tight regulation to prevent excessive tissue breakdown. Another associated pathway is the inflammation response pathway. Here it influences processes where protease-driven inflammation can lead to tissue damage connecting with other proteases that modulate inflammatory processes.
SERPINB13 has connections to chronic inflammatory disorders and cancers of stratified epithelium. Research suggests its altered expression associates with oral squamous cell carcinoma a type of cancer affecting the tongue and mouth. The protein’s dysregulation can lead to imbalance in ECM remodeling and inflammation processes in which SERPINB13 is implicated alongside MMPs and other related serpins. Understanding SERPINB13's role in these pathologies provides potential for studying disease mechanisms and therapeutic targets.