Abcam, ab236425, Anti-XRCC6BP1/KUB3 antibody [OTI5F3]

Size: 100µL
Mouse Monoclonal XRCC6BP1/KUB3 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ATP23.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:OTI5F3,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human ATP23.Q9Y6H3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Purification notes-Purified from cell culture supernatant., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
XRCC6BP1 also known as KUB3 is a protein that plays a mechanical role in maintaining genome stability. It has a molecular mass of approximately 81 kDa. XRCC6BP1 exhibits expression in a variety of tissues but it has higher levels in areas with active cell proliferation. Its functions involve interactions with other proteins to ensure the structural integrity of DNA.
Biological function summary
XRCC6BP1 participates in the repair of DNA double-strand breaks important for preventing genomic instability. It forms part of multi-protein complexes that facilitate correct DNA damage recognition and repair. XRCC6BP1 engages in interactions with proteins involved in non-homologous end joining an important DNA repair pathway. By doing this it supports cellular responses to DNA damage maintaining a correct cellular cycle.
Pathways
XRCC6BP1 integrates DNA repair processes into broader signaling networks. It actively participates in the non-homologous end joining pathway important for DNA repair. XRCC6BP1 also connects to the homologous recombination repair pathway indicating its versatile role. Related proteins such as XRCC6 (Ku70) and XRCC5 (Ku80) identify and bind to DNA break sites facilitating the recruitment of XRCC6BP1 for repair synthesis.
XRCC6BP1's function correlates with cancer and some genetic disorders. Deficiencies or dysfunctions in XRCC6BP1 can lead to improper DNA repair contributing to genomic instability an important feature in cancer development. Research also investigates its disruptions in disorders such as ataxia-telangiectasia where repair mechanisms fail. Its relationship with other proteins involved in these diseases such as ATM signifies its impact on maintaining DNA integrity under stress conditions.