Abcam, ab236584, Anti-MPC2 antibody

Size: 100µL
Rabbit Polyclonal MPC2 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MPC2 aa 1-50.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MPC2 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.O95563

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MPC2 also known as Mitochondrial Pyruvate Carrier 2 is a protein that resides in the inner mitochondrial membrane. It functions as part of a carrier complex that imports pyruvate into mitochondria. The protein has a molecular mass of approximately 15 kDa. MPC2 is expressed in various tissues with high expression observed in metabolically active tissues like muscle and liver where it plays an important role in cellular energy metabolism.
Biological function summary
The function of MPC2 involves its role in forming the MPC (Mitochondrial Pyruvate Carrier) complex with MPC1. This complex is important for the transport of pyruvate into the mitochondria a necessary step in cellular respiration and energy production. The effective functioning of the MPC complex is essential for the proper execution of oxidative phosphorylation which ultimately leads to ATP generation.
Pathways
The mitochondrial pyruvate import facilitated by MPC2 plays an important role in the citric acid cycle (Krebs cycle) and the overall process of glycolysis. These pathways are central to cellular metabolism enabling cells to convert glucose into usable energy. Additionally MPC2 interacts indirectly with proteins involved in the electron transport chain as its activity influences the substrate availability for these downstream processes.
MPC2's function is linked to metabolic disorders and conditions. Defects or deficiencies in MPC2 function can lead to disruptions in energy homeostasis contributing to diseases such as diabetes and certain mitochondrial disorders. The protein shares connections with insulin signaling pathways as disruptions here can exacerbate glucose intolerance and insulin resistance.