Abcam, ab236654, Anti-FFAR3/GPR41 antibody

Size: 100µL
Rabbit Polyclonal FFAR3/GPR41 antibody. Suitable for WB and reacts with Mouse samples. Cited in 9 publications. Immunogen corresponding to Recombinant Fragment Protein within Human FFAR3 aa 250 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human FFAR3 aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.O14843

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Free fatty acid receptor 3 (FFAR3) also known as GPR41 is a G-protein coupled receptor. It is part of a family of receptors sensing short-chain fatty acids mainly propionate and acetate. The receptor has a mass of about 41 kDa. It is expressed mostly in intestinal tissues adipose tissue and the peripheral nervous system. FFAR3 helps in monitoring and responding to the levels of these fatty acids in various physiological contexts.
Biological function summary
FFAR3 acts as a sensor and regulator of energy balance in the body. It is not part of a large protein complex but instead directly interacts with its ligands the short-chain fatty acids to modulate signaling pathways. FFAR3 primarily influences the release of hormones like insulin and leptin contributing to metabolic homeostasis. This receptor plays a significant role in converting dietary nutrients into energy signals.
Pathways
FFAR3 integrates into the signaling control of the gut-brain axis and energy regulation. It participates actively in the cAMP signaling pathway which includes interactions with other receptors such as the FFAR2. Through these pathways it supports cellular responses essential for maintaining glucose and lipid metabolism balance. These processes are important for adapting to changes in dietary intake and ensuring homeostatic energy management.
FFAR3 associates with metabolic conditions including type 2 diabetes and hypertension. Its function in regulating insulin and energy levels links it to both of these conditions. Furthermore interaction with proteins like adenylate cyclase involved in the cAMP pathway also ties it to these diseases. Studying FFAR3 is valuable for understanding and potentially modulating metabolic disorders making it an important target for therapeutic investigations.