Abcam, ab236724, Anti-NOP58 antibody

Size: 100µL
Rabbit Polyclonal NOP58 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human NOP58.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human NOP58.Q9Y2X3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NOP58 also known as Nop58p is a nucleolar protein involved in the biogenesis of small nucleolar ribonucleoproteins (snoRNPs). This protein weighs approximately 58 kDa. Researchers find NOP58 expressed in the nucleolus of eukaryotic cells. NOP58 is part of the box C/D small nucleolar RNA (snoRNA) complex which plays a critical role in the maturation and modification of pre-rRNA.
Biological function summary
NOP58 contributes to the assembly and function of snoRNPs which guide the chemical modification of rRNA particularly 2'-O-methylation. This modification has significance for proper ribosome assembly and function. NOP58 does not work alone; it forms part of a complex with other proteins such as NOP56 Fibrillarin and SNU13. These proteins come together to accurately target and chemically modify specific rRNA sequences.
Pathways
NOP58 participates in the ribosome biogenesis and rRNA processing pathways. These pathways are essential for producing the ribosomal units required for protein synthesis. NOP58 functions alongside proteins like NOP56 and Fibrillarin in modifying rRNA which is critical within the nucleolus. Proper functioning of these pathways ensures the cell maintains protein synthesis efficiency and accuracy.
Alterations in NOP58 may affect nucleolar function potentially leading to ribosomopathies. Disruptions in NOP58 can potentially associate with conditions such as cancer where nucleolar activity is often altered. Proteins like Fibrillarin associated with snoRNP complexes may also be implicated in these diseases as they share involvement in similar pathways and complex functions with NOP58.