Abcam, ab236726, Anti-Claudin 20 antibody

Size: 100µg / 100µL
Rabbit Polyclonal Claudin 20 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CLDN20 aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human CLDN20 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.P56880

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Claudin 20 also known as CLDN20 is a protein that functions as a structural component in tight junctions. Claudins are a group of proteins important for the maintenance of cell polarity and barrier function in epithelial and endothelial cell layers. Claudin 20 has a low molecular weight of approximately 23 kDa. This protein is predominantly expressed in the kidney lung and intestines indicating its functional significance in these organs.
Biological function summary
Claudin 20 contributes to the paracellular transport by creating selective permeability barriers between epithelial cells. It associates with other claudin proteins to form tight junction strands within the cellular structure. These strands regulate the passage of ions and small molecules thereby maintaining the homeostasis of tissues. The protein often interacts with ZO-1 which is a tight junction-associated protein to stabilize its position within the junction.
Pathways
Claudin 20 plays an integral role in the epithelial barrier function pathway. It is central in maintaining the integrity and permeability of epithelial barriers working alongside proteins such as claudin 1 and claudin 4. It also contributes to the developmental and maintenance aspects of tight junctions participating in the signaling pathways that control cellular adhesion and communication. Alterations in these pathways can lead to varied physiological responses.
Claudin 20 has been implicated in certain kidney disorders such as nephrotic syndrome due to its role in maintaining the glomerular filtration barrier. It also relates to lung diseases like pulmonary fibrosis where tight junction integrity is compromised. Claudin 20 interacts with other claudin proteins such as claudin 16 in the development and progression of these conditions highlighting its significant role in disease pathology.