Abcam, ab236772, Anti-IPP antibody

Size: 100µL
Rabbit Polyclonal IPP antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human IPP aa 400-550.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human IPP aa 400-550. The exact immunogen used to generate this antibody is proprietary information.Q9Y573

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The molecule isopentenyl pyrophosphate (IPP) sometimes referred to as isopentenyl diphosphate serves as an important intermediate in the biosynthesis of terpenes and isoprenoids. IPP a small molecule with a molecular mass of 246.1 g/mol participates in various enzymatic reactions within the mevalonate pathway. This pathway occurs in the cytosol of eukaryotic cells and the peroxisomes in plants. In terms of its expression while IPP is not a protein or gene with specific expression levels the enzymes related to its synthesis and utilization show varying activity across different tissues.
Biological function summary
IPP functions as a precursor for various essential isoprenoid compounds encompassing sterols dolichols and ubiquinones. It acts within a network of enzymes converting basic building blocks into complex molecules that maintain cell membranes and facilitate electron transport. These reactions often involve enzyme complexes like synthases that regulate the flow of intermediates. Moreover IPP plays a substantial role in the synthesis of other molecules like cholesterol and steroid hormones reflecting its broad biological influence.
Pathways
IPP engages prominently in the mevalonate and the methylerythritol phosphate (MEP) pathways. The mevalonate pathway produces isoprenoids which are vital for cell growth and development. Within these pathways IPP can interconvert with dimethylallyl pyrophosphate (DMAPP) another critical molecule. Enzymes like HMG-CoA reductase and isopentenyl-diphosphate isomerase control these reactions linking IPP to key biological pathways involved in metabolic regulation and cellular differentiation.
IPP's significance links to disorders related to cholesterol metabolism and immune system dysregulation. Defects in the mevalonate pathway associate with diseases like mevalonate kinase deficiency influencing levels of inflammatory proteins. Moreover IPP accumulation can activate immune cells through the recognition by Vγ9/VΔ2 T-cells implicating it in conditions such as autoimmunity or inflammation. This connection highlights the consequence of IPP in understanding metabolic and immune-related disorders.