Abcam, ab236784, Anti-NEDL2 antibody

Size: 100µL
Rabbit Polyclonal NEDL2 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human HECW2 aa 450-650.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human HECW2 aa 450-650. The exact immunogen used to generate this antibody is proprietary information.Q9P2P5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NEDD4 E3 ubiquitin protein ligase-like 2 commonly known as NEDL2 functions as an E3 ubiquitin ligase. It plays a role in protein degradation through the ubiquitin-proteasome system. NEDL2 is approximately 130 kDa in mass. It is expressed in various tissues with higher levels detected in the brain and testis. NEDL2 facilitates the transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to a substrate protein marking it for degradation or regulating its activity.
Biological function summary
NEDL2 mediates protein ubiquitination a process influencing protein stability and function. NEDL2 associates with cellular signaling pathways impacting cellular homeostasis and stress responses. It functions independently but can also interact with other protein complexes to modulate their activities. The ubiquitination process controlled by NEDL2 contributes to the cellular regulation by targeting specific proteins for degradation thereby affecting various cellular processes.
Pathways
NEDL2 integrates into the ubiquitin-proteasome pathway a core mechanism for controlled protein degradation. It interacts with proteins like E2 ubiquitin-conjugating enzymes to perform its function. Another critical pathway that involves NEDL2 is the Wnt signaling pathway where ubiquitination processes influence signal transduction. NEDL2's interactions help maintain proper cellular function by regulating protein levels ensuring correct pathway activation or inhibition.
NEDL2 has links to neurodegenerative diseases and cancer. Its dysfunction may disrupt protein homeostasis contributing to conditions like Alzheimer's disease. In such cases improper ubiquitination can lead to the accumulation of misfolded proteins exacerbating disease progression. Additionally NEDL2's interactions with tumor suppressor proteins imply its potential role in oncogenesis. Altered NEDL2 activity might affect tumor suppressor degradation influencing cancer development and progression.