Abcam, ab236852, Anti-TMEM19 antibody

Size: 100µL
Rabbit Polyclonal TMEM19 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Transmembrane protein 19 aa 100-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Transmembrane protein 19 aa 100-250. The exact immunogen used to generate this antibody is proprietary information.Q96HH6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TMEM19 also known as transmembrane protein 19 is a protein with a molecular mass of approximately 23 kDa. Researchers have identified it as a transmembrane protein common in several tissues including the brain and heart. The protein operates to ensure proper cellular processes by contributing to the structural integrity and communication between cells. It remains important for understanding the role it plays in cell membrane dynamics.
Biological function summary
TMEM19 functions by participating in cellular signaling and membrane organization. It does not act alone often forming complexes with other membrane proteins to stabilize interactions at the cell surface. This role allows it to influence various cellular activities like transport and cellular recognition impacting several physiological functions. Understanding its behavior is important for insights into cellular communication mechanisms.
Pathways
Several studies indicate TMEM19's involvement in pathways related to cellular transport and membrane trafficking. It associates with the endocytosis pathway playing a part in vesicle formation and intracellular signaling. TMEM19 interacts with proteins such as clathrin which is important for these pathways. This connection suggests its importance in maintaining the balance of protein and lipid uptake in cells.
TMEM19 has been linked to neurological impairments and cardiovascular conditions. Mutations or alterations in its expression might relate to disorders like epilepsy and cardiac arrhythmias. It interacts with proteins involved in these conditions such as ion channels and amyloid precursor protein. These associations make TMEM19 a candidate of interest in disease mechanisms and potential therapeutic targeting.