Abcam, ab236854, Anti-TMEM53 antibody

Size: 100µL
Rabbit Polyclonal TMEM53 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TMEM53 aa 1-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TMEM53 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.Q6P2H8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TMEM53 also known as Transmembrane Protein 53 is a protein that functions primarily as a transmembrane protein. It is composed of 190 amino acids giving it a molecular weight of approximately 22 kDa. TMEM53 is expressed across various tissues but it shows notably high expression in the liver and kidney. Structurally it includes multiple transmembrane domains which suggest its role in cellular transport or signaling processes.
Biological function summary
TMEM53 contributes to maintaining cellular homeostasis and signaling. It has been implicated in various cellular pathways where it helps regulate ion transport across membranes. Though not part of any known complex TMEM53 interacts with components of the cell membrane influencing cellular responses to external stimuli. The protein's ubiquitous presence in body tissues highlights its broad functional roles.
Pathways
TMEM53 engages in signal transduction and ion transport pathways. One example is the calcium signaling pathway where it regulates intracellular calcium levels. The protein works alongside ion transporters like SLC8A1 also known as the sodium/calcium exchanger to modulate cellular ion balance. Its pathway involvement points to interactions with other transmembrane proteins that support cellular communication and nutrient exchange.
TMEM53 has been connected to hypertension and kidney disease. Research indicates that alterations in TMEM53 expression or function can influence blood pressure regulation. This connection seems related to its role in sodium transport pathways similar to the actions of proteins like ENaC the epithelial sodium channel. Additionally changes in TMEM53 activity can impact kidney function leading to chronic kidney disorders highlighting its relevance in renal health.