Abcam, ab236880, Anti-RPL38 antibody

Size: 100µL
Rabbit Polyclonal RPL38 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human 60S ribosomal protein L38.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human 60S ribosomal protein L38.P63173

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RPL38 also known as Ribosomal Protein L38 is a component of the 60S subunit of ribosomes. It has a mass of approximately 9.4 kDa. You find this protein expressed in various tissues across the human body with higher expression in certain regions of the brain and reproductive organs. The primary role of RPL38 involves orchestrating the assembly and stabilization of ribosomal structures aiding in the translation of messenger RNA into proteins.
Biological function summary
The integration of RPL38 within the ribosomal complex is necessary for proper ribosome function. As a part of the large 60S ribosomal subunit RPL38 contributes to maintaining structural integrity and facilitating the catalytic process of peptide bond formation which is essential in protein synthesis. Ribosomal proteins including RPL38 collaborate to ensure fidelity and efficiency during the translation process.
Pathways
RPL38 influences critical cellular processes associated with mRNA translation and protein synthesis. Its role in the translational machinery links it to the broader pathway of protein biosynthesis. Additionally RPL38 aligns with the mTOR signaling pathway which oversees cell growth and proliferation. Within these pathways RPL38 cooperates with other ribosomal proteins and elements such as S6K1 and eIF4E contributing to the regulation of protein translation within cells.
RPL38 connects with several conditions through its involvement in protein synthesis. Abnormalities or mutations in RPL38 have associations with specific developmental disorders such as Diamond-Blackfan anemia a rare blood disorder. Furthermore disruptions in the function of ribosomal proteins like RPL38 also relate to cancer where dysfunctional protein synthesis can promote uncontrolled cell proliferation. The link between RPL38 and other ribosomal proteins like RPL5 and RPL11 is significant in understanding their combined contributions to these diseases.