Abcam, ab236899, Anti-SFT2D2 antibody

Size: 100µL
Rabbit Polyclonal SFT2D2 antibody. Suitable for WB, ICC/IF and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SFT2D2 aa 1-50.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SFT2D2 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.O95562

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SFT2D2 also known as Suppressor of Fused (Sof1) in yeast is a protein involved in membrane trafficking and sorting within cells. It has a mass of approximately 21 kDa and is localized in the membranes of the Golgi apparatus and cytoplasmic vesicles. Expression of SFT2D2 occurs in various tissues with high levels observed in the liver and kidney. The protein possesses transmembrane domains that allow it to facilitate movement of vesicles between organelles.
Biological function summary
SFT2D2 plays a role in the Golgi apparatus' function and vesicular transport processes. It is part of a larger protein complex that helps mediate vesicle fusion and cargo transport. This protein ensures accurate sorting and delivery of proteins and lipids which are essential for maintaining cellular homeostasis. It is especially vital in regulating the processing and maturation of proteins that transit through the secretory pathway.
Pathways
SFT2D2 functions in the intracellular trafficking and secretory pathways. It interacts with the SNARE protein family to perform its role in vesicle docking and fusion. Additionally SFT2D2 has relevance in the secretory pathway where it contributes to the optimal functioning of the endoplasmic reticulum (ER) to Golgi transport. This coordination with proteins such as Syntaxin 5 ensures seamless progression of synthesized proteins to their destinations.
Alterations in SFT2D2 expression or structure might relate to metabolic dysfunctions including liver diseases. Disruption to SFT2D2 pathways also indicates a potential link to neurodegenerative disorders due to impaired vesicular trafficking. Relatedly improper association with SNARE proteins can exacerbate these conditions highlighting the importance of SFT2D2 in disease pathogenesis. Understanding its role could aid in discovering therapeutic targets in related disorders.