Abcam, ab236979, Anti-FILIP1L antibody

Size: 100µL
Rabbit Polyclonal FILIP1L antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human FILIP1L aa 1-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human FILIP1L aa 1-200. The exact immunogen used to generate this antibody is proprietary information.Q4L180

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FILIP1L also known as FILIP-1-like protein is a protein with a mass of approximately 136 kDa. Mechanically FILIP1L interacts with the actin cytoskeleton affecting cell shape and motility. It modulates cell adhesion by interacting directly with filamin A a cytoskeletal protein. FILIP1L expression occurs in various tissues including the brain heart and liver. Its presence influences cellular architecture through actin binding.
Biological function summary
FILIP1L regulates cell migration and growth. It serves as an important mediator of cellular signaling that influences cytoskeletal dynamics. Although not a part of a multi-protein complex FILIP1L's role extends to the regulation of cell division and apoptosis. It modulates responses to extracellular signals contributing to processes such as cell proliferation and differentiation. Researchers focus on FILIP1L for its dual role in promoting cellular stability and flexibility.
Pathways
FILIP1L plays critical roles in the Wnt and TGF-beta signaling pathways. It works alongside proteins like beta-catenin and SMAD2/3 to influence gene transcription related to cell cycle control and apoptosis. FILIP1L's interaction with these pathways supports its role in maintaining proper cellular communication. The pathways regulate development differentiation and homeostasis reflecting the importance of FILIP1L in broader cellular functions.
FILIP1L associates with cancer and neurological disorders. Cancer studies indicate that FILIP1L expression levels affect tumor progression linked with altered cell migration and invasion. In neurological disorders its role in the brain suggests potential involvement in conditions like neurodegenerative diseases. FILIP1L interacts with proteins such as filamin A and SMAD proteins emphasizing its involvement in both tumor biology and neural health. Understanding FILIP1L better offers insights into therapeutic strategies.