Abcam, ab236990, Anti-KAR antibody

Size: 100µL
Rabbit Polyclonal KAR antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human HSD17B12 aa 1-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human HSD17B12 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.Q53GQ0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Kainate receptors (KARs) are ionotropic receptors important for fast excitatory neurotransmission. They are also known as 'kainate-type glutamate receptors' and are part of the larger glutamate receptor family. The typical mass of these receptors can vary due to different subunits but they usually range between 100 and 120 kDa. KARs express in the central nervous system especially in regions such as the hippocampus and cortex. They involve in synaptic transmission and plasticity through their role as ligand-gated ion channels.
Biological function summary
KARs participate in mediating excitatory synaptic transmission and are part of a complex with other ion channels and receptors like AMPA and NMDA receptors. They regulate synaptic strength and plasticity which are important for learning and memory processes. Active in both pre- and postsynaptic sites KARs can either enhance or inhibit neurotransmitter release affecting neuronal excitability. Their ability to modulate other neurotransmitter systems highlights their diverse influence on neural circuits.
Pathways
KARs are critical components in the glutamatergic signaling pathway which includes AMPA and NMDA receptors as well. They work closely with these proteins to regulate synaptic plasticity and excitatory neurotransmission. Investigations show the involvement of KARs in the long-term potentiation pathway important for memory encoding. Additionally they overlap with metabotropic glutamate receptors influencing intracellular signaling cascades and calcium dynamics.
KARs have associations with epilepsy and neurodegenerative diseases like Alzheimer's disease. Dysfunctional KAR signaling can lead to altered neuronal excitability contributing to epilepsy pathogenesis. Moreover in Alzheimer's altered glutamatergic transmission due to impaired KAR function associates with memory deficits. Their connection with AMPA and NMDA receptors is significant here as these proteins also pertain to synaptic dysfunction and cognitive impairments observed in these conditions.