Abcam, ab236991, Anti-NAALADL2 antibody

Size: 100µL
Rabbit Polyclonal NAALADL2 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human NAALADL2 aa 100 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human NAALADL2 aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q58DX5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NAALADL2 also known as N-acetylated alpha-linked acidic dipeptidase-like 2 functions mechanically as a type II transmembrane glycoprotein. It participates in peptide hydrolysis and it is related to the prostate-specific membrane antigen (PSMA) family. The protein has an approximate mass of 85 kDa. Researchers have observed its expression in several tissues with a higher presence in the prostate and certain reproductive tissues. The protein also localizes in the epithelial cells where it potentially plays a role in modulating peptide signaling.
Biological function summary
NAALADL2 is involved in controlling levels of N-acetylaspartylglutamate a neuropeptide that functions as a neurotransmitter. Despite its mechanical similarity to PSMA NAALADL2 does not participate in the folate metabolism. Instead its role centers around peptide processing and regulation without being known as part of a specific protein complex. Its actions in the hydrolysis of peptide bonds affect neural communication and possibly cellular signaling in the tissue where it is expressed.
Pathways
Peptide metabolism and hydrolysis are important processes in which NAALADL2 is involved. It is linked to pathways governing neurotransmitter regulation and could impact excitatory signaling in neurons through its regulation of peptide intermediates. In these pathways NAALADL2 is related to proteins that manage neurotransmitter dynamics like NAALADase due to similarities in their functions and regulatory roles.
Researchers have explored connections between NAALADL2 and prostate cancer. Elevated levels of this protein occur in certain prostate cancer types suggesting a role in cancer progression or development. The protein shares similarity with PSMA which has established roles in prostate cancer pathology. Understanding this relationship could lead to targeted therapeutic interventions focusing on modulating its expression or activity. Additionally scientists consider its neuropeptide interaction in the context of neural disorders although more research is necessary to elucidate any direct links.