Abcam, ab237030, Anti-FOXE3 antibody

Size: 100µL
Rabbit Polyclonal FOXE3 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human FOXE3 aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human FOXE3 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.Q13461

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FOXE3 also known as forkhead box E3 is a transcription factor weighing approximately 33 kDa. It exhibits expression predominantly in the eye lens particularly during development. As a member of the forkhead family of transcription factors FOXE3 plays key roles in the regulation of gene expression. Mammalian species show high conservation of FOXE3 gene sequences reflecting its importance across different organisms.
Biological function summary
Interaction with other proteins is important for FOXE3's function particularly in the differentiation of lens fiber cells and lens development. This transcription factor ensures proper lens morphogenesis maintaining transparency and preventing cataract formation. Though its primary activity lies in the eye FOXE3 can influence other tissues by regulating gene expression pertinent to epithelial cell development. Current data suggests FOXE3 does not form large multi-protein complexes but interacts with specific gene promoters to exert its function.
Pathways
FOXE3 activity integrates into the lens development and morphogenesis pathways. It regulates genes such as CRYAA and MIP important for lens transparency and cell differentiation. FOXE3 works closely with PAX6 and SOX2 proteins that are also pivotal in the eye development pathway. These interactions highlight its integral role in eye development processes and maintenance of tissue homeostasis within the ocular microenvironment.
FOXE3 mutations or dysregulation associate with congenital cataracts and anterior segment dysgenesis. Anomalies in FOXE3 expression can cause severe developmental disorders in the eye leading to visual impairment or blindness. The PAX6 gene can also contribute to similar disorders establishing a genetic linkage between the two in their disease manifestations. Researchers continue to explore FOXE3's involvement in these pathologies to develop potential therapeutic strategies.