Abcam, ab237050, Anti-CBWD2 antibody

Size: 100µL
Rabbit Polyclonal CBWD2 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ZNG1B aa 50 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ZNG1B aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q8IUF1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CBWD2 also known as Cobalt Chelatase D Homolog 2 is a human protein weighing approximately 36 kDa. Mechanically CBWD2 functions in metal ion binding particularly with cobalt ions. This protein locates itself in the cytosol and is expressed across various tissues although specific expression levels can vary. CBWD2 participates in metal homeostasis and may interact with other proteins involved in metal processing.
Biological function summary
The protein CBWD2 plays a role in maintaining metal ion balance within cells important for cellular processes that involve metal cofactors. It is thought to be part of a larger protein complex that regulates metal ion transport and storage. This complex aids in protecting cells from metal toxicity and ensures proper functioning of enzymatic reactions that need metal ions as cofactors.
Pathways
CBWD2 participates in metal ion transport and detoxification pathways. It interacts with proteins involved in the transport of metal ions across cellular membranes. For instance CBWD2 shows functional relationships with metallothioneins known for binding heavy metals and with proteins in the cation transport pathway. This is integral for balancing metal ion distribution and mitigating potential metal-induced oxidative stress.
CBWD2 may have relevance to conditions such as metal ion imbalance and neurodegenerative disorders that involve metal deposition like Alzheimer's disease. Alterations in CBWD2 expression or function could disrupt metal homeostasis contributing to the pathology of these diseases. Moreover its interactions with metallothioneins and proteins regulating metal transport suggest that CBWD2 might be significant in conditions related to metal ion dysregulation.