Abcam, ab237052, Anti-NDRG4 antibody

Size: 100µL
Rabbit Polyclonal NDRG4 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human NDRG4 aa 200-350.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human NDRG4 aa 200-350. The exact immunogen used to generate this antibody is proprietary information.Q9ULP0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NDRG4 also known as N-Myc downstream-regulated gene 4 is a protein that functions mechanically in cellular processes such as growth and differentiation. Its molecular mass is approximately 43 kDa. This protein is widely expressed in various tissues with notable expression in the heart brain and skeletal muscle. NDRG4 plays a role in cellular stress response and signal transduction by undergoing phosphorylation which aids in the modulation of its activity.
Biological function summary
NDRG4 participates in nervous system development and proper functioning. It is involved in axon growth and guidance important for neuron connectivity. While NDRG4 does not often form part of large protein complexes it interacts with other proteins to facilitate these processes. For instance it coordinates with signaling molecules to affect cytoskeletal dynamics and myelination contributing to neural maintenance.
Pathways
Scientists recognize NDRG4's involvement in signaling pathways like the MAPK pathway pivotal in transmitting extracellular signals to the nucleus to promote cell survival and differentiation. In this pathway NDRG4 interacts with proteins such as ERK1/2 highlighting its role in signal transduction. Another relevant pathway is the PI3K/Akt pathway where NDRG4 influences cell growth and metabolism through interactions with proteins like PI3K further emphasizing its significance in cellular health and function.
Prominently studied ones connected to NDRG4 include cancer and neurological disorders. In cancer alterations in NDRG4 expression can correlate with tumor growth potentially through its interaction with metastasis-related proteins such as NDRG1. Regarding neurological disorders alterations in NDRG4 expression or function have been linked to Alzheimer's disease connecting it with amyloid-beta peptide accumulation and tau protein pathology suggesting its involvement in neurodegeneration.