Abcam, ab237056, Anti-DPY19L3 antibody

Size: 100µL
Rabbit Polyclonal DPY19L3 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human DPY19L3 aa 550-700.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human DPY19L3 aa 550-700. The exact immunogen used to generate this antibody is proprietary information.Q6ZPD9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
DPY19L3 also known as dpy-19-like C-mannosyltransferase 3 is a member of the DPY19 family of proteins. It is expressed in various tissues with significant presence in the testis brain and heart. This protein has a mass of about 75 kDa. DPY19L3 functions as a C-mannosyltransferase an enzyme responsible for transferring mannose to specific tryptophan residues on proteins. Its activity is critical for proper protein glycosylation which affects how proteins fold and maintain stability.
Biological function summary
The function of DPY19L3 plays a vital role in protein modification and localization in cells. It is part of the glycosylation process and interacts with other C-mannosyltransferases to facilitate this process. Glycosylation is essential for protein sorting and function impacting signaling pathways and cellular responses. DPY19L3 often collaborates with DPY19L2 and DPY19L4 which assist in similar enzymatic processes ensuring proteins reach their destinations within the cell.
Pathways
DPY19L3 is integral to N-glycosylation and O-glycosylation pathways. These pathways are essential for producing glycoproteins that have various cellular functions from signaling to immune responses. DPY19L3 interacts with proteins such as mannose transferases and other glycosylation enzymes like MGAT1. Such interactions highlight DPY19L3's importance in generating properly folded and functional proteins including those in immune cell signaling pathways and cell adhesion processes.
DPY19L3 has been associated with fertility issues and certain types of cancer. Alterations in its enzymatic activity can lead to improper protein glycosylation affecting sperm function and contributing to male infertility. Additionally changes in glycosylation patterns due to DPY19L3 mutation may affect cancer cell proliferation and metastasis. This protein is also connected with dysregulated pathways involving proteins like DPY19L2 suggesting potential overlap in disease mechanisms and outcomes between these family members.