Abcam, ab237486, Anti-ZNF529 antibody

Size: 100µL
Rabbit Polyclonal ZNF529 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ZNF529 aa 350 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ZNF529 aa 350 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q6P280

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity greater than 95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZNF529 also known as Zinc Finger Protein 529 functions as a transcription factor. Its primary role involves binding to specific DNA sequences influencing gene expression. ZNF529 has an approximate molecular weight of 79 kDa. Expression of ZNF529 occurs in several tissues with notable presence in the brain and reproductive organs. Its zinc finger motifs enable it to interact with diverse genetic elements affecting the transcriptional landscape.
Biological function summary
ZNF529 participates in regulating developmental processes and differentiation pathways. The protein acts as part of a transcriptional control complex interacting with other regulatory proteins to modulate specific gene sets. By influencing the expression of genes involved in cell growth and survival ZNF529 plays a critical role in maintaining cellular functions. Researchers have linked these interactions to processes such as neuronal development and tissue-specific gene expression.
Pathways
ZNF529 contributes to key pathways like the Wnt signaling pathway and the Notch signaling pathway. Within these pathways it interacts with significant proteins such as beta-catenin in Wnt signaling and the Notch intracellular domain in Notch signaling. These pathways are essential for processes such as embryonic development and stem cell maintenance. ZNF529 aids in the regulation and balance of these pathways highlighting its role in cellular communication and signaling networks.
Abnormal ZNF529 expression associates with neurological disorders and certain cancers. Dysregulation of ZNF529 may lead to conditions such as schizophrenia where its interplay with proteins like DISC1 has been observed. Additionally ZNF529 may contribute to tumorigenesis through interaction with cancer-associated proteins such as p53. Understanding ZNF529's involvement in these diseases could provide insights into potential therapeutic targets.