Abcam, ab237502, Anti-NRSN1/VMP antibody

Size: 100µL
Rabbit Polyclonal NRSN1/VMP antibody. Suitable for WB, ICC/IF and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human NRSN1 aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human NRSN1 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.Q8IZ57

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity greater than 95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NRSN1/VMP also known as Neurensin-1 is a transmembrane protein with a molecular mass around 17 kDa. The protein predominantly expresses in neuronal tissues including the central and peripheral nervous systems. NRSN1 localizes to the membrane of small round vesicles where it appears to partake in vesicle trafficking due to its transmembrane nature.
Biological function summary
Neurensin-1 impacts neuronal development and function. It may be involved in synaptic plasticity and axonal transport although the exact biological functions are not fully extracted. Some studies suggest Neurensin-1 participates as part of a larger protein complex located in the neuronal growth cone thereby influencing cellular dynamics in neurons.
Pathways
Current data links Neurensin-1 to the endocytosis and nerve growth factor signaling pathways. These pathways are key to maintaining neuronal health and supporting neurogenesis. Neurensin-1 has demonstrated interactions with clathrin and dynamin essential proteins within these pathways revealing its importance in vesicle-mediated transport processes.
Neurensin-1 shows possible connections to neurodegenerative diseases such as Alzheimer's and Parkinson's. Neurensin-1 may influence these conditions through its interactions with proteins like amyloid-beta in Alzheimer's disease and alpha-synuclein in Parkinson's disease suggesting a role in pathological protein aggregation or clearance in neuronal cells.