Abcam, ab237534, Anti-PFDN2 antibody

Size: 100µL
Rabbit Polyclonal PFDN2 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human PFDN2.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human PFDN2.Q9UHV9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity greater than 95%, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The prefoldin subunit 2 protein also known as PFDN2 plays an important role in chaperone-mediated protein folding. The protein has an approximate mass of 16 kDa. Scientists have observed its expression in many tissues including the brain liver and muscle. PFDN2 forms part of the prefoldin complex which participates in assisting nascent protein chains to fold correctly.
Biological function summary
PFDN2 functions to stabilize unfolding proteins by housing them in its prefoldin complex until they achieve proper conformation. This complex interacts directly with the cytoskeleton to maintain cellular architecture. The prefoldin complex consists of six subunits including PFDN2 that work together to perform this chaperone role effectively.
Pathways
PFDN2 contributes significantly to both the tubulin and actin folding pathways. This involves its interaction with chaperonins including CCT (chaperonin-containing TCP-1) important for the assembly of the cytoskeleton. It's vital in managing protein dynamics thereby influencing cellular activities like motility and division through its collaborative action with these pathways.
PFDN2 has associations with neurodegenerative conditions such as spinal muscular atrophy and amyotrophic lateral sclerosis. Researchers often study its interactions with other proteins such as SMN1 and SOD1 involved in these diseases. Dysregulation or mutations within PFDN2-related pathways could contribute to the progression of these disorders making it an area of active investigation for therapeutic interventions.