Abcam, ab237537, Anti-MRAP2 antibody

Size: 100µL
Rabbit Polyclonal MRAP2 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MRAP2 aa 50 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MRAP2 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q96G30

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity greater than 95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MRAP2 also known as Melanocortin-2 Receptor Accessory Protein 2 is a protein that modulates the activity of melanocortin receptors primarily MC4R. It has a molecular mass of about 16 kDa and is expressed in several regions of the brain including the hypothalamus. MRAP2 plays a role in supporting the function of these receptors by facilitating their trafficking and increasing their functionality on the cell surface.
Biological function summary
MRAP2 interacts with the melanocortin system which involves energy balance and appetite regulation. It forms a complex with melanocortin receptors especially MC4R and to some extent MC3R influencing signaling pathways that control food intake. This system is fundamental in the regulation of metabolism reflecting the importance of MRAP2 in maintaining energy homeostasis in organisms.
Pathways
MRAP2 operates within the melanocortin pathway interacting closely with the leptin signaling pathway which governs energy expenditure and appetite. MRAP2 supports the function of MC4R which in turn relates to the regulation of adenylyl cyclase activity affecting cAMP levels. MC4R is also involved in the leptin-melanocortin pathway showing how MRAP2 assists in linking energy intake and energy expenditure processes.
MRAP2 impacts conditions like obesity and metabolic syndrome due to its influence on energy balance and metabolic processes. Dysfunctional MRAP2 activity has associations with leptin receptor pathways which can lead to altered appetite regulation and weight gain. Additionally MRAP2 has links with genetic conditions involving MC4R that contribute to weight disorders.