Abcam, ab237589, Anti-C9orf72 antibody [EPR22021] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal C9orf72 antibody. Carrier free. Suitable for WB and reacts with Rat, Mouse, Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR22021,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab237589 is the carrier-free version of
ab221137
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
C9orf72 also known as Chromosome 9 Open Reading Frame 72 is a protein with a molecular mass of approximately 54 kDa. This protein is abundantly expressed in the brain particularly in neurons and is also present in other tissues including muscle and blood. Mechanically C9orf72 is involved in nucleocytoplasmic transport and plays a role in autophagy a process important for cell maintenance by degrading and recycling cellular components.
Biological function summary
C9orf72 supports normal cellular homeostasis through its role in autophagy and lysosomal function. It forms part of a protein complex with WDR41 and SMCR8 contributing to the regulation of the small GTPases of the Rab family. C9orf72 affects trafficking and degradation of vesicles processes important for neuronal health and function.
Pathways
C9orf72 interacts with several cellular mechanisms involved in the regulation of autophagy and endosomal trafficking. It is an important player in the mTOR signaling pathway which is significant for cell growth proliferation and survival. C9orf72 also associates with the ULK1 complex connecting it to the early steps of autophagy induction. These interactions suggest that C9orf72 may influence various cellular processes through its regulatory functions.
Alterations in C9orf72 are closely associated with neurodegenerative diseases such as Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). Mutations or expansions in the C9orf72 gene contribute to these conditions by disrupting normal protein function leading to neuronal damage and degeneration. The protein is connected to TDP-43 which deposits abnormally in tissues of ALS and FTD patients linking it to the pathophysiology of these disorders.