Abcam, ab237615, Anti-GSDMA antibody

Size: 100µL
Rabbit Polyclonal GSDMA antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human GSDMA aa 50-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human GSDMA aa 50-200. The exact immunogen used to generate this antibody is proprietary information.Q96QA5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity greater than 95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein GSDMA also known as Gasdermin-A is a member of the gasdermin family. It has a molecular mass of approximately 47 kDa. GSDMA is expressed mainly in the epithelial tissues including the skin gastrointestinal tract and several internal organs. This expression pattern suggests its connection to protective barriers and cellular signaling processes. GSDMA shares functional characteristics with other gasdermin proteins such as the ability to form pores in membranes which can lead to cell death through pyroptosis.
Biological function summary
GSDMA influences processes related to cell death and inflammation. It acts as a pore-forming molecule in response to specific cellular stress signals. Although it is not typically part of larger protein complexes itself GSDMA works in concert with other cellular components to facilitate the regulated death of cells often in the context of immune responses. This protein plays an important role in controlling tissue homeostasis and preventing aberrant inflammatory reactions.
Pathways
GSDMA engages mainly in the pyroptosis and inflammatory pathways. It collaborates with proteins such as caspase-1 and components of the NLR (NOD-like receptor) family during these processes. The gasdermin-mediated cleavage events ensure that cells undergo programmed inflammatory cell death when necessary which highlights GSDMA's role in immune surveillance and pathogen clearance.
GSDMA is linked to certain inflammatory conditions and skin disorders. Variations in GSDMA expression or function have been associated with conditions like asthma and atopic dermatitis. Interactions with proteins involved in inflammation such as IL-18 may underline these connections. Understanding these linkages provides insight into potential therapeutic targets for treating such inflammatory disorders.