Abcam, ab237622, Anti-AGXT2 antibody

Size: 100µL
Rabbit Polyclonal AGXT2 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human AGXT2 aa 150-350.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human AGXT2 aa 150-350. The exact immunogen used to generate this antibody is proprietary information.Q9BYV1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity greater than 95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
AGXT2 also known as alanine--glyoxylate aminotransferase 2 is an enzyme with approximately 56 kDa mass. The enzyme is expressed mainly in the liver kidney and heart. AGXT2 catalyzes the transamination reaction between alanine and glyoxylate to produce pyruvate and glycine. It is critical for the cellular detoxification processes and the regulation of amino acid metabolism.
Biological function summary
This enzyme contributes to the conversion of glyoxylate therefore preventing its accumulation which can be harmful. AGXT2 is not part of a larger protein complex but it works closely with other enzyme systems involved in amino acid metabolism. Its activity maintains the balance between glycolate and glycine levels within the body which is essential for normal cellular function.
Pathways
AGXT2 functions in both the glyoxylate and dicarboxylate metabolism pathway as well as the broader amino acid metabolism pathways. Within these pathways its role connects it to other related proteins such as Glyoxylate reductase/hydroxypyruvate reductase (GRHPR) and Lactate dehydrogenase. These interactions contribute to maintaining homeostasis in intermediary metabolism.
AGXT2 abnormalities relate closely to primary hyperoxaluria type 2 and certain cardiovascular diseases. Mutations or deficiencies in AGXT2 can result in the overproduction of oxalate leading to kidney stone formation and renal damage. Additionally reduced AGXT2 activity might influence homocysteine levels potentially linking it to cardiovascular disorders. This relationship places AGXT2 in connection with other proteins such as cystathionine beta-synthase in the context of homocysteine metabolism.