Abcam, ab237734, Anti-C1GALT1 antibody

Size: 100µL
Rabbit Polyclonal C1GALT1 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Recombinant Fragment Protein within Human C1GALT1 aa 1-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human C1GALT1 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.Q9NS00

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
C1GALT1 also known as core 1 β13-galactosyltransferase is an enzyme important for the synthesis of core 1 O-glycans. The enzyme has a molecular mass of approximately 55 kDa. It localizes in the Golgi apparatus where it actively participates in glycosylation processes. C1GALT1 shows widespread expression in various tissues including the liver lungs and intestines. By catalyzing the transfer of galactose to N-acetylgalactosamine on proteins it plays an important role in O-glycan biosynthesis.
Biological function summary
The function of C1GALT1 extends to modifying proteins that impact cell-cell interactions protein stability and signaling pathways. C1GALT1 does not work alone but as a part of a complex with chaperone protein COSMC which is necessary for its glycosyltransferase activity. This complex formation is essential to ensure the proper structure and function of the resulting glycoproteins which have a broad range of impacts in cell biology and communication.
Pathways
C1GALT1 plays a significant role in the mucin-type O-glycan biosynthesis pathway which is critical for producing mucins. These proteins are important for protective mucus barriers in several organs. C1GALT1 shows interaction with galectin proteins that recognize specific glycan structures influencing cellular processes such as adhesion and migration. Additionally it participates in the PI3K-Akt signaling pathway which links to cell growth and survival often intersecting with pathways involving other glycosyltransferases.
C1GALT1 has associations with IgA nephropathy also known as Berger's disease where abnormal glycosylation patterns of IgA1 occur. This disorder often involves the misfunction of proteins like C1GALT1 and COSMC. Furthermore aberrant C1GALT1 activity may have links to cancer progression as improper glycosylation can impact tumor cell migration and invasion. C1GALT1's interplay with galectins and other glycoproteins influences these pathological conditions making it a focal point for understanding and potentially targeting these diseases.