Abcam, ab237735, Anti-JAGN1 antibody

Size: 100µL
Rabbit Polyclonal JAGN1 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human JAGN1 aa 1-50.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human JAGN1 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.Q8N5M9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity greater than 95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
JAGN1 also known as Jagunal homolog 1 is a protein expressed in various tissues including the bone marrow and immune cells. The protein has a mass of approximately 18 kDa. JAGN1 plays a role in the endoplasmic reticulum where it is involved in the process of protein maturation and trafficking. It is a vital component in ensuring proper glycosylation of proteins which is important for their stability and function.
Biological function summary
The protein aids in cellular processes linked to immune cell function and development. It forms part of a complex that participates in the secretory pathway influencing how proteins are processed and transported within cells. This involvement directly impacts the immune response as it ensures that immune cells mature correctly and are functionally active.
Pathways
JAGN1 plays a significant role in the N-linked glycosylation pathway an important process necessary for protein folding and stability. It interacts with other proteins like Dolichyl-Diphosphooligosaccharide-Protein Glycosyltransferase to effectively carry out its glycosylation functions. Another important pathway includes the unfolded protein response pathway which involves proteins like IRE1 and PERK important for maintaining cellular homeostasis under stress conditions.
JAGN1 has been linked to severe congenital neutropenia a disorder affecting the production and function of neutrophils important immune cells. Mutations in the JAGN1 gene have been observed in patients with this condition leading to increased vulnerability to infections. Furthermore research suggests a potential connection with asthma where it may affect immune cell function and inflammatory responses. Through these conditions JAGN1 interacts with proteins like ELANE and CSF3R further elucidating its importance in immune-related diseases.