Abcam, ab237776, Anti-Uroplakin Ia antibody [4B4]

Size: 20µg / 100µg / 1mg
Mouse Recombinant Monoclonal Uroplakin Ia antibody. Suitable for IHC-P and reacts with Mouse, Rat samples.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:4B4,
Isotype:IgG1,
Carrier free:No,
Reacts with:Mouse, Rat,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Uroplakin Ia also known as UP1a or UPK1A is a transmembrane protein with a molecular mass of approximately 28 kDa. This protein forms an integral part of the asymmetric unit membrane (AUM) in the urothelial cells of the bladder. It mainly occurs in the apical surface of these cells contributing to the mechanical stability and permeability barrier function of the urothelium. Uroplakin Ia's structural role helps protect underlying tissues from harmful urine components.
Biological function summary
As part of the larger uroplakin complex Uroplakin Ia plays a critical role in the differentiation and formation of the urothelial plaques. It combines with other uroplakin family members including Uroplakin Ib Uroplakin II and Uroplakin III to form this protein complex ensuring proper surface architecture. The complex importantly enhances the urothelium's protective barrier function allowing the bladder to effectively retain urine.
Pathways
Uroplakin Ia participates in the maintenance of urothelial cell junction integrity. This protein interacts particularly within the urothelial differentiation pathway and is essential for surface assembly. It shares pathways with proteins like Uroplakin II which further support the integrity and function of bladder epithelial cells. These interactions help uphold the structural integrity necessary for normal bladder function.
Uroplakin Ia shows associations with bladder cancer and interstitial cystitis. Alterations in the expression or function of this protein could contribute to the disrupted barrier function observed in these conditions. Uroplakin Ia also shows connections to other uroplakin proteins such as Uroplakin III which could influence the severity or progression of diseases mentioned. Researchers explore these links further to develop potential diagnostic and therapeutic approaches.