Abcam, ab237801, Anti-CEP70 antibody

Size: 100µL
Rabbit Polyclonal CEP70 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CEP70 aa 50-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human CEP70 aa 50-300. The exact immunogen used to generate this antibody is proprietary information.Q8NHQ1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity greater than 95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CEP70 also known as Centrosomal Protein 70kDa is a component of the centrosome and involved in microtubule organization. The protein has a molecular mass of approximately 70 kDa. It is expressed in several tissues with significant expression observed in the brain and testis. CEP70 plays an important role in maintaining the structural integrity and function of the centrosome contributing to cell cycle progression by ensuring accurate splitting during cell division.
Biological function summary
CEP70 contributes to the regulation of microtubule dynamics. It is known to localize at the centrosome and participates actively in the assembly of the bipolar spindle. CEP70 interacts within a complex network of proteins including CEP135 and γ-tubulin facilitating the stabilization of microtubules and supporting spindle microtubule nucleation. These interactions ensure proper chromosomal alignment and segregation during mitosis.
Pathways
Several cellular processes involve CEP70's integration into essential pathways like the mitotic spindle assembly and cell cycle regulation. It associates with proteins such as CEP135 and γ-tubulin influencing pathways that oversee cell cycle checkpoints and spindle formation. The efficient functioning of these pathways is important for proper cell division highlighting CEP70's role in maintaining genomic stability and preventing aneuploidy.
CEP70 has implications in conditions related to abnormal cell division such as certain cancers and microcephaly. In cancer alterations in CEP70 expression or function can contribute to unregulated cell proliferation owing to its influence on mitotic spindle dynamics. Furthermore CEP70's interaction with proteins like CEP135 is significant in understanding genetic disorders linked to centrosome dysfunctions including microcephaly where impaired centrosome activity affects brain development.