Abcam, ab237802, Anti-AACS antibody

Size: 100µL
Rabbit Polyclonal AACS antibody. Suitable for IP, WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human AACS aa 400-600.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human AACS aa 400-600. The exact immunogen used to generate this antibody is proprietary information.Q86V21

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity greater than 95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
AACS also known as acetoacetyl-CoA synthetase plays a role in ketone body metabolism. This enzyme has a molecular mass of about 74 kDa and facilitates the conversion of acetoacetate into acetoacetyl-CoA. AACS expression is noticeable in tissues like the liver and brain where high energy demand exists. By helping in ketone body utilization AACS provides an important link in energy metabolism pathways.
Biological function summary
Acetoacetyl-CoA synthetase contributes significantly to lipid synthesis and energy production processes. It activates acetoacetate to form acetoacetyl-CoA an essential intermediate in cholesterol and fatty acid synthesis. Acetoacetyl-CoA plays an important role acting in sequential steps with acetyl-CoA and other enzymes to form more complex lipid molecules although the AACS enzyme does not form a complex itself.
Pathways
The role of AACS connects particularly to the ketone body and the acetyl-CoA biosynthetic pathways. AACS facilitates acetoacetate utilization in the aforementioned pathways enabling energy generation alongside enzymes such as HMG-CoA synthase and fatty acid synthase. The interaction among these enzymes highlights the integration of ketone metabolism within broader metabolic networks.
Faulty AACS functions have links to metabolic syndromes like diabetes and neurological disorders such as Alzheimer's disease. In diabetes improper ketone body utilization can lead to metabolic imbalance potentially involving enzymes like insulin receptor kinases. Within Alzheimer's disease deviances in lipid synthesis pathways where AACS is involved can contribute to disease progression due to altered energy metabolism in brain tissues.