Abcam, ab238340, Anti-STK38 antibody

Size: 100µL
Rabbit Polyclonal STK38 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human STK38 aa 1-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human STK38 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.Q15208

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
STK38 also known as NDR1 (nuclear Dbf2-related kinase 1) is a serine/threonine kinase with a molecular mass of approximately 54 kDa. It plays an important role in the regulation of cell proliferation and apoptosis through its involvement in phosphorylation processes. This protein is expressed in various tissues including the brain heart and muscle indicating its broad functional roles across different biological systems. Through its kinase activity STK38 modulates several intracellular pathways critical for maintaining cellular functions.
Biological function summary
STK38 is essential for regulating apoptosis and cell cycle progression. It acts as part of a larger signaling complex engaging in interactions with different proteins to exert its effects. Phosphorylation by STK38 often leads to activation or inhibition of downstream targets influencing cell survival and division. It can interact with MOB1 and LATS1/2 which highlights its role in the Hippo signaling pathway important for controlling organ size and suppressing tumors.
Pathways
The STK38 protein integrates itself into the Hippo and mTOR pathways. In the Hippo pathway its interactions with MOB1 and LATS proteins are important for regulating organ size and maintaining balance between cell growth and death. In the mTOR pathway STK38 influences metabolic processes and cell growth by modifying signal transduction that is critical for cellular homeostasis. These pathways are vital for normal cellular function and highlight the regulatory versatility of STK38.
STK38 plays a significant role in cancer and neurodegenerative diseases. Aberrant activity or expression levels of STK38 can contribute to the development of certain cancers due to dysregulated cell proliferation and survival. In neurodegenerative diseases improper functioning of STK38 can lead to loss of neuronal cell integrity and increased cell death. Through its interactions with cancer-related proteins such as YAP1 and neurologically relevant proteins alterations in STK38 signaling may exacerbate disease progression.