Abcam, ab238506, Anti-EPX antibody

Size: 100µL
Rabbit Polyclonal EPX antibody. Suitable for IHC-P and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human EPX aa 100-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human EPX aa 100-300. The exact immunogen used to generate this antibody is proprietary information.P11678

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
EPX also known as eosinophil peroxidase or e p x is an enzyme with a molecular mass of approximately 71 kDa. This enzyme is mainly expressed in eosinophils a type of white blood cell involved in the immune response. EPX is located in the granules of eosinophils and it plays a role in the catalysis of halide ions and hydrogen peroxide to produce hypohalous acids which are potent antimicrobial agents. These acids contribute to the killing of bacteria and other pathogens making the enzyme a critical component of the immune system.
Biological function summary
Eosinophil peroxidase participates in the body's defense against parasitic infections and allergic reactions. It is not known to be a part of a larger protein complex but it does interact with other proteins within the immune response setting. EPX helps in generating reactive oxygen species which have antimicrobial properties and are important in immune signaling pathways. Although it can lead to tissue damage when overproduced its controlled activity is necessary for effective immune function.
Pathways
Eosinophil peroxidase's activity intersects with the respiratory burst pathway and the detoxification pathway. The enzyme contributes to the formation of reactive oxygen species in the respiratory burst pathway which is important for pathogen destruction. EPX is also connected with enzymes like myeloperoxidase (MPO) that function similarly in the immune response though EPX is more specific to eosinophils. This specialization makes it an important player in eosinophil-associated diseases and disorders.
Eosinophil peroxidase has links to asthma and allergic diseases. Its activity in producing reactive oxygen species and hypohalous acids can exacerbate airway inflammation in asthma resulting in tissue damage. Additionally EPX has been studied in the context of autoimmune conditions as its dysregulated activity may contribute to inflammation. Its interaction with other proteins like myeloperoxidase could also influence such diseases highlighting the enzyme's role in pathological processes beyond its beneficial antimicrobial functions.