Abcam, ab238551, Anti-CHAD antibody

Size: 100µL
Rabbit Polyclonal CHAD antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CHAD.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human CHAD.O15335

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CHAD known as Chondroadherin is a protein that plays a mechanical role in cartilage structure. It has a molecular mass of approximately 38 kDa. You can find CHAD expressed mainly in cartilage tissues where it contributes to maintaining the integrity of the extracellular matrix. The protein interacts with other matrix components allowing it to help stabilize cartilage structure and function.
Biological function summary
CHAD takes part in cell adhesion and interaction within cartilage tissue. It does not typically form a complex with other proteins instead functioning by binding to collagen fibrils and integrins. This binding action promotes the linkage between cells and the extracellular matrix important for maintaining healthy cartilage. CHAD's role in cell adhesion underlines its importance in tissue-specific functions and structural support.
Pathways
CHAD functions within the cartilage development pathway specifically contributing to extracellular matrix organization. It interacts with proteins like collagen and integrins strengthening structural network essential for cartilage durability. Another relevant pathway is the integrin signaling pathway where CHAD influences cellular responses to mechanical stimuli aligning its role with tissue maintenance and repair processes.
CHAD relates closely to osteoarthritis a condition characterized by the degeneration of cartilage. The protein's interaction with collagen and integrins might influence cartilage resilience potentially affecting the progression of osteoarthritis. Moreover CHAD's presence and function also connect it to cartilage-related disorders encompassing its relationship with collagen and integrins both vital in maintaining cartilage health.