Abcam, ab238875, Anti-LY6H antibody

Size: 100µL
Rabbit Polyclonal LY6H antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human LY6H aa 1 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human LY6H aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.O94772

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity greater than 95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The LY6H protein also known as lymphocyte antigen 6 complex locus H is part of the Ly6/uPAR/alpha-neurotoxin superfamily. It has a mass of approximately 14 kDa. Research has shown that LY6H localizes mainly in the membrane of human neurons. It can be found in the brain and spinal cord emphasizing its importance in nervous tissue. LY6H undergoes glycosylation which seems essential for its stability or function.
Biological function summary
LY6H contributes significantly to neural processes. It acts as a modulator of neuronal signaling and synaptic plasticity important for learning and memory. This protein does not function as an individual unit; instead it forms part of a complex network with other proteins to influence neurotransmission. Understanding its role in these processes can provide insights into neural development and function.
Pathways
LY6H integrates into the neurotrophin signaling pathway and the CREB signaling pathway. These pathways are critical for cell survival development and differentiation in the nervous system. It interacts with proteins like NTRK receptors and BDNF highlighting its role in facilitating proper neural function and response to environmental stimuli.
LY6H has links to neurological diseases including Alzheimer’s disease and schizophrenia. Alterations in LY6H expression or function could potentially disrupt normal neural processes contributing to these conditions. It connects to proteins such as amyloid-beta in Alzheimer’s disease and DISC1 in schizophrenia which may help illuminate the pathology and provide potential therapeutic targets.