Abcam, ab238911, Anti-COPT2 antibody

Size: 100µL
Rabbit Polyclonal COPT2 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SLC31A2 aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SLC31A2 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.O15432

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity greater than 95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
COPT2 also known as COPTI or Copper Transporter 2 functions mechanically as a transporter protein responsible for moving copper ions across cell membranes. It facilitates the import of essential copper ions into the cells integral for various cellular processes. The mass of COPT2 is approximately 27 kilodaltons. It is mainly expressed in the liver kidneys and brain where cells demand efficient copper ion regulation.
Biological function summary
COPT2 plays an important role in maintaining copper homeostasis within the body allowing proper cellular functions that require copper-dependent enzymes. COPT2 is not part of a protein complex but its significance lies in its singular ability to enhance cellular uptake of copper ions. Copper-dependent enzymes such as cytochrome c oxidase and superoxide dismutase rely on COPT2's function to maintain optimal activity within the cell.
Pathways
COPT2 is directly involved in the copper regulation pathway ensuring that cells receive sufficient copper ions for enzymatic activities. This pathway also interacts with metallothioneins which are proteins responsible for metal detoxification and storage. COPT2's function complements other copper transport proteins like ATP7A and ATP7B which help in exporting and distributing copper within the body.
Disturbances in COPT2 function contribute to conditions such as Wilson's disease and Menkes disease. Wilson's disease results from copper accumulation due to impaired copper transport while Menkes disease involves defective copper absorption. COPT2 works alongside proteins like ATP7B in Wilson's disease and ATP7A in Menkes disease highlighting its important involvement in managing copper ion levels and maintaining cellular health.