Abcam, ab238912, Anti-Myoneurin antibody

Size: 100µL
Rabbit Polyclonal Myoneurin antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MYNN aa 50-350.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MYNN aa 50-350. The exact immunogen used to generate this antibody is proprietary information.Q9NPC7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity greater than 95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Myoneurin also known as MYNN is a protein involved in transcription regulation. This protein has a molecular mass of approximately 78 kDa. It shows expression in a variety of tissues but is particularly enriched in the skeletal muscle and central nervous system. Myoneurin's role stems from its capacity to interact with DNA and influence the transcription of specific genes which makes it significant in cellular and developmental processes.
Biological function summary
Myoneurin contributes to regulating gene expression. It acts as a part of multi-protein complexes required in nucleosome remodeling and transcription activation. Through these complexes Myoneurin alters chromatin structure facilitating the accessibility of transcription factors to DNA. This function is important for the fine-tuning of gene expression that affects cell cycle progression and differentiation especially within muscular and neural contexts.
Pathways
Several processes partly depend on Myoneurin. Notably it involves the muscle cell differentiation pathway and neural development. It interacts with proteins such as MEF2 a transcription factor that modulates gene expression in muscle cells and CREB implicated in long-term memory formation both participating in gene regulatory networks coordinated by Myoneurin. These interactions suggest its role in gene pathways that govern tissue-specific functional outcomes.
Myoneurin is linked to certain muscular and neurodegenerative conditions. Alterations or deficiencies in Myoneurin expression relate to muscle atrophy and have been studied in contexts like muscular dystrophies. Additionally Myoneurin's interaction with proteins like SMN linked with spinal muscular atrophy highlights its potential involvement in neuromuscular disorders. Understanding these connections could advance therapeutic strategies for these diseases.