Abcam, ab239030, Anti-RGS20 antibody

Size: 100µL
Rabbit Polyclonal RGS20 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human RGS20 aa 1-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human RGS20 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.O76081

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RGS20 also known as Regulator of G-protein Signaling 20 is a protein that functions mechanically as a GTPase-activating protein (GAP) for G-alpha subunits of heterotrimeric G proteins. It accelerates the termination of G-protein coupled receptor (GPCR) signaling pathways by increasing the GTPase activity of the G-alpha subunit. The protein has a molecular mass of approximately 26 kDa. RGS20 is expressed in various tissues with high levels in the brain and some expression in peripheral tissues such as the spleen and lung.
Biological function summary
RGS20 modulates signal transduction by accelerating the deactivation of G-proteins which plays an important role in regulating GPCR signaling. It associates with G-beta and G-gamma forming a complex that allows for more efficient signal regulation. The activity of RGS20 is vital in neuronal signaling processes within the brain contributing to regulation of neurotransmitter release and synaptic plasticity.
Pathways
RGS20 influences several G-protein mediated pathways such as the cAMP signaling pathway and the MAPK pathway. It interacts with the G-alpha subunits like G-alpha i and G-alpha q influencing the pathways' duration and intensity. RGS20's regulation of these pathways affects various cellular responses including cell growth and differentiation.
RGS20 relates to neurological disorders and cancer. Altered expression of RGS20 has been observed in some types of brain tumors and neurodegenerative diseases. It is associated with dopamine receptors that are implicated in disorders like schizophrenia and Parkinson's disease. Changes in RGS20 expression or function can affect signaling pathways related to these conditions making it an important protein for research in therapeutic targeting.