Abcam, ab239081, Anti-DGKZ/DGK-zeta antibody [EPR22040-80]

Size: 20µL / 100µL / 1mL
Anti-DGKZ/DGK-zeta antibody [EPR22040-80] (ab239081) is a rabbit monoclonal antibody detecting DGKZ/DGK-zeta in Western Blot, Flow Cytometry (Intra), Flow Cytometry, IHC-P, ICC/IF, mIHC . Suitable for Human, Mouse, Rat . - Multiplex IHC validated on the Leica BOND® MAX using Opal reagents - Biophysical QC for unrivalled batch-batch consistency
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR22040-80,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:ICC/IF, WB, IHC-P, Flow Cyt (Intra), mIHCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
What is this antibody validated in?
Anti-DGKZ/DGK-zeta antibody [EPR22040-80] (ab239081) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF), Multiplex IHC (mIHC) in Human, Mouse, Rat samples.
What is the molecular weight of DGKZ/DGK-zeta?
Anti-DGKZ/DGK-zeta [EPR22040-80] (ab239081) specifically detects a band for DGKZ/DGK-zeta (UniProt: Q13574) at a molecular weight of 124kDa.
Trial sizes available!
Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl.
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Other related products
We have a range of other formats of antibody clone [EPR22040-80] also available for your convenience: ab239081, Carrier free -
ab239790
, Alexa Fluor® 647 -
ab270107
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
DGKZ also known as DGK-zeta or DGK? is an enzyme that belongs to the diacylglycerol kinase family and plays an important role in lipid signaling pathways. The 'zeta' isoform of DGK sometimes noted in scientific literature as DGK ART and DGK MEXICO catalyzes the conversion of diacylglycerol (DAG) to phosphatidic acid (PA) by ATP-dependent phosphorylation impacting signal transduction. DGKZ has a molecular mass of approximately 115 kDa. It shows expression in various tissues including brain heart and skeletal muscle with higher expression levels typically seen in the nervous system where it affects neurotransmitter signaling.
Biological function summary
DGKZ influences cellular processes such as growth differentiation and apoptosis by regulating DAG and PA levels. It forms part of a complex network of proteins involved in intracellular signaling cascades exerting effects on protein kinase C (PKC) activity. The regulatory function of DGKZ within cellular activity highlights its role in maintaining normal cellular homeostasis and responding to extracellular signals. Its enzymatic activity influences DAG-mediated pathways which are important for the activation and deactivation of downstream signaling proteins.
Pathways
DGKZ plays a critical role within the signaling pathways such as the phosphoinositide signaling and mTOR pathways. It serves as an important modulator of lipid signaling within the diacylglycerol- and phosphatidic acid-mediated signaling pathways impacting protein interactions and signaling mechanisms. Other proteins related through these pathways include PKC and mTOR with which DGKZ interacts to modulate functions such as cell proliferation and survival. The enzymatic conversion of DAG to PA by DGKZ actively regulates the availability of these lipid signaling molecules and therefore modulates their downstream effects.
DGKZ has associations with neurological disorders and cancer. Abnormal regulation or expression of DGKZ contributes to pathologies such as Alzheimer's disease where impaired lipid signaling affects neuronal function and survival. Additionally its dysregulation may promote cancer progression through aberrant cell signaling pathways. DGKZ interacts with proteins like PKC which play a role in these diseases making it a potential therapeutic target. Understanding its function and interactions helps offer insights into the development of targeted therapies for these conditions.