Abcam, ab239962, Anti-S100 Calcium Binding Protein A13/S100A13 antibody [EPR4510] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal S100 Calcium Binding Protein A13/S100A13 antibody. Carrier free. Suitable for IHC-P, IP, WB, ICC/IF, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR4510,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:ICC/IF, Flow Cyt (Intra), IHC-P, IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab239962 is the carrier-free version of
ab109252
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please
contact us
for more information.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
S100 Calcium Binding Protein A13 also known as S100A13 is a member of the S100 protein family and displays calcium-binding abilities usually binding two calcium ions. This small protein has a molecular mass of approximately 11 kDa. S100A13 is expressed in a variety of tissues including the heart brain and skeletal muscle. Its expression can be altered in different cellular conditions suggesting an adaptive role in diverse physiological contexts.
Biological function summary
S100A13 influences several cellular processes related to growth and differentiation. This protein facilitates secretion of fibroblast growth factor 1 (FGF1) and interleukin-1 alpha (IL-1α) through a non-classical pathway. S100A13 does not function alone; it engages in complexes with other proteins to execute its roles. It often works together with S100A6 and calcyclin-binding protein in these secretory pathways.
Pathways
S100A13 participates in the regulation of angiogenesis and inflammation. It is involved in the FGF signal transduction pathway by affecting the externalization of FGF1 an important player in angiogenesis. Additionally S100A13 contributes to inflammation-related processes. Its activity is linked to proteins such as p53 and FGF1 integrating it into wider cellular systems.
S100A13 is implicated in cancer and chronic inflammatory conditions. Overexpression of S100A13 has links to tumor progression and aggressiveness suggesting a role in cancer. In chronic inflammation S100A13 associates with increased levels of inflammatory cytokines. It connects to proteins like FGF1 and IL-1α in these contexts linking it with pathophysiological mechanisms that underlie these conditions.