Abcam, ab240581, Anti-IPS1 antibody

Size: 100µg
Rabbit Polyclonal IPS1 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human PPIP5K1 aa 1350 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human PPIP5K1 aa 1350 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q6PFW1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
IPS1 also known as MAVS (Mitochondrial Antiviral-Signalling protein) functions at the mechanical level as an important adaptor protein in antiviral immune responses. It exhibits a mass of approximately 56 kDa and is predominantly expressed in the mitochondria of various cells especially immune cells. IPS1 interacts with downstream signaling molecules to execute its functions. It plays an important role by acting as a bridge that links cytosolic sensors of viral RNA to the activation of transcription factors.
Biological function summary
IPS1 mediates the innate immune response against viruses by facilitating the production of type I interferons and inflammatory cytokines. Upon detection of viral components IPS1 forms signalosome complexes with proteins like RIG-I and MDA5 that sense viral RNA. These interactions enable the recruitment of downstream effectors that activate transcription factors such as IRF3 IRF7 and NF-kB leading to an antiviral state. The ability of IPS1 to form these complexes makes it a central modulator in the immune signaling cascade.
Pathways
Different signaling events rely on IPS1 for the propagation of immune signals. IPS1 operates within the RIG-I-like receptor (RLR) pathway an essential component of innate antivirus defense. It plays a pivotal role in signaling cascades that start from RIG-I and MDA5 leading to the activation of IRF and NF-kB transcription factors. These interactions highlight IPS1's integration in pathways that orchestrate cellular responses to viral infection.
IPS1 connects significantly to viral infections and related immune dysfunctions. Abnormal IPS1 signaling can contribute to the pathogenesis of diseases such as hepatitis and systemic lupus erythematosus (SLE). For instance defective interactions between IPS1 and proteins like RIG-I or MDA5 can impair the proper immune response to viral infections leading to chronic infection or inflammatory disorders. Additionally its involvement in triggering inappropriate immune responses further links it to autoimmune conditions such as SLE.