Abcam, ab240646, Anti-GMEB1 antibody [EPR23056-62]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal GMEB1 antibody. Suitable for IP, WB, ICC/IF, Flow Cyt (Intra), IHC-P and reacts with Human, Mouse, Rat samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR23056-62,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, IP, WB, ICC/IF, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The GMEB1 protein also known as Glucocorticoid Modulatory Element Binding Protein 1 serves as a transcriptional coactivator involved in regulating gene expression. It weighs approximately 57 kDa and is found mainly in the nucleus due to its role in transcriptional processes. GMEB1 is expressed in various tissues with noticeable levels in neural tissues and other organ systems. The protein influences cellular processes by interacting with DNA and other transcription factors therefore modulating the transcriptional machinery.
Biological function summary
GMEB1 plays a significant role in gene expression by forming complexes with other transcription factors and binding specific DNA elements. GMEB1 interacts with both nuclear and cytoplasmic proteins affecting cellular functions such as proliferation differentiation and apoptosis. It is known to modulate the activity of certain steroid hormone receptors impacting physiological responses to hormonal signals. Through these interactions GMEB1 assists in mediating the response to cellular stress and contributes to overall cellular homeostasis.
Pathways
GMEB1 contributes to regulating the glucocorticoid receptor signaling pathway and the apoptotic pathways. It interacts with proteins like the glucocorticoid receptor influencing how cells respond to glucocorticoid hormones. Additionally GMEB1 participates in signaling that determines cell survival and programmed cell death making it significant in maintaining cell integrity. The protein ensures proper cellular response to stimuli integrating signals from multiple pathways and modulating cellular outcomes accordingly.
GMEB1 has implications in cancer and neurological disorders. Aberrant expression or dysfunction of GMEB1 can contribute to tumorigenesis as its role in cell cycle regulation and apoptosis becomes compromised. GMEB1’s interaction with steroid hormone receptors links to breast cancer influencing disease progression and treatment response. Moreover GMEB1 has importance in neurological conditions through its expression in neural tissues and potential involvement in neuronal signaling and survival potentially impacting disorders like Alzheimer's disease.