Abcam, ab240696, Anti-UBFD1 antibody

Size: 100µg
Rabbit Polyclonal UBFD1 antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human UBFD1 aa 150-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human UBFD1 aa 150-200. The exact immunogen used to generate this antibody is proprietary information.O14562

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab240696 was affinity purified using an epitope specific to UBFD1 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
UBFD1 also known as Ubiquitin Family Domain-Containing Protein 1 is a protein with a molecular mass of approximately 35 kDa. It functions mechanically by interacting with ubiquitin tags playing a role in protein degradation and localization through the ubiquitin-proteasome system. UBFD1 is expressed in various tissues with notable expression in the liver brain and immune cells. This widespread expression suggests its involvement in multiple cellular functions.
Biological function summary
UBFD1 engages in cellular homeostasis by influencing protein turnover and signaling pathways. It is not known as part of a traditional protein complex but it interacts with several ubiquitin-associated proteins. UBFD1 regulates the stability of proteins by mediating their ubiquitination status which affects the cell cycle DNA repair and response to stress conditions. Its role is important for maintaining normal cellular function and preventing the accumulation of damaged proteins.
Pathways
UBFD1 influences many cellular processes notably the ubiquitin-proteasome pathway and the DNA damage response pathway. It works closely with proteins such as ubiquitin-conjugating enzymes and substrate-specific ubiquitin ligases. These pathways are integral to maintaining protein homeostasis and ensuring proper cellular responses to damage and stress. By modulating these pathways UBFD1 ensures effective protein management and repair mechanisms within the cell.
UBFD1 is linked to neurodegenerative diseases and certain types of cancer. Abnormal regulation or mutations in UBFD1 may contribute to protein misfolding and aggregation seen in diseases like Alzheimer's. In cancer UBFD1 dysfunction may lead to unregulated cell division due to impaired protein degradation. Studies have shown interactions between UBFD1 and proteins such as p53 highlighting its relevance in cancer pathogenesis through disruption of normal cell cycle control.