Abcam, ab240699, Anti-ZNF592 antibody

Size: 20µg / 100µL
Rabbit Polyclonal ZNF592 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ZNF592 aa 200-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ZNF592 aa 200-250. The exact immunogen used to generate this antibody is proprietary information.Q92610

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZNF592 also known as Zinc Finger Protein 592 is a protein with a molecular mass of approximately 148 kDa. It performs its functions as a transcriptional regulator due to its zinc finger domains which facilitate DNA binding. Researchers have observed its expression across various tissues including the central nervous system where it likely has significant roles due to its regional specificity. By binding to specific DNA sequences ZNF592 regulates the transcription of associated genes influencing cellular processes and development.
Biological function summary
The protein affects neural development and function playing important roles in maintaining the stability of neuron processes. It becomes part of transcriptional regulatory complexes where it interfaces with other proteins to modulate gene expression related to neuronal differentiation. Its activity helps guide the appropriate formation and maintenance of neural networks which are essential for correct brain function. Studies suggest ZNF592 works in regulation with various neuronal transcription factors adding layers of control to the expression pattern of neural genes.
Pathways
ZNF592 has significant contributions to the neurogenesis and neural differentiation pathways where it modulates the expression of key regulatory genes. It operates in relation to pathways involving other important transcription factors like REST (repressor element 1-silencing transcription factor) and soforth ensures the maintenance of neural progenitor cell identity and lineage specification. ZNF592 interacts with these factors to balance cell proliferation and differentiation in the central nervous system.
Mutations or dysregulation of ZNF592 link to neurological conditions such as intellectual disabilities and spinocerebellar ataxia. These conditions reflect the protein’s critical function in neural development and the delicate balance of neuronal cell regulatory mechanisms. In particular ZNF592 associates with the protein Ataxin-1 where they together may contribute to the development of spinocerebellar ataxia type 1 revealing potential pathogenic pathways involving faulty transcriptional regulation in neural tissues. Understanding these connections prompts further research into therapeutic strategies targeting these dysfunctions.