Abcam, ab241069, Anti-ZNF703 antibody

Size: 100µg
Rabbit Polyclonal ZNF703 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human ZNF703 aa 100-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ZNF703 aa 100-150. The exact immunogen used to generate this antibody is proprietary information.Q9H7S9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Antibody was affinity purified using an epitope specific to ZNF703 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZNF703 also known as Zinc Finger Protein 703 weighs about 62 kDa. This protein functions as a transcription factor playing a significant role in the regulation of gene expression. It mainly localizes to the nucleus where it binds to specific DNA sequences to exert its effects. Reports indicate ZNF703 expression in various tissues such as embryonic stem cells and different cancer types suggesting its importance in development and disease states.
Biological function summary
The involvement of ZNF703 in transcription regulation is critical for cellular processes. Acting as part of the transcriptional repressor complexes ZNF703 interacts with other proteins such as CtBP1 and CtBP2. This interaction results in modulation of the expression of genes that are important for cell cycle progression and developmental pathways. Research highlights its regulatory function in balancing cell proliferation and differentiation impacting both normal and pathological conditions.
Pathways
ZNF703 interacts with several important signaling networks including the E2F and Wnt pathways. Through these interactions ZNF703 influences cell cycle regulation and proliferation. Within these pathways ZNF703 interacts with proteins such as E2F transcription factors and β-catenin which play roles in cell cycle control and developmental processes. These connections illustrate how ZNF703 integrates into a larger cellular network to sustain proper cellular function.
Researchers associate ZNF703 with breast cancer and glioblastoma. Amplification and overexpression of ZNF703 in breast cancer correlate with aggressive tumor phenotypes highlighting its role as an oncogene. ZNF703 also interacts with other cancer-related proteins like MYC enhancing its role in driving tumor progression. Moreover studies indicate ZNF703 overexpression in glioblastoma where it contributes to uncontrolled cell proliferation providing insights into its potential as a therapeutic target.