Abcam, ab241276, Anti-YKT6 antibody

Size: 100µg
Rabbit Polyclonal YKT6 antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human Synaptobrevin homolog YKT6 aa 100 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human Synaptobrevin homolog YKT6 aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.O15498

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab241276 was affinity purified using an epitope specific to YKT6 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
YKT6 also known as Synaptobrevin-like 2 is a SNARE protein involved in vesicular transport. YKT6 has a molecular mass of about 23 kDa and is present across various tissues notably in the brain and pancreas. This protein does not have a transmembrane domain which allows cycling between membrane-bound and cytosolic forms contributing to its role in membrane fusion processes.
Biological function summary
YKT6 aids in the regulation of membrane fusion events important for the secretory pathway. It operates as part of the SNARE complex which includes other proteins like VAMPs syntaxin and SNAP-25. These components form a tight complex that brings vesicle and target membranes into close proximity driving the fusion necessary for intracellular transport and secretion.
Pathways
YKT6 connects to exocytosis and endocytosis pathways which are important for neurotransmitter release and cellular uptake processes. It interacts with proteins such as SNAP-25 and syntaxins within these pathways. As a SNARE protein YKT6's role in vesicle trafficking is vital for maintaining cellular homeostasis and regulating signal transmission across synapses.
Abnormalities in YKT6 expression or function impact neurodegenerative diseases like Alzheimer's disease. Altered interactions between YKT6 and other proteins such as syntaxin can disrupt normal synaptic function and contribute to pathogenesis. Additionally irregular YKT6 activity may play a role in certain cancers where vesicular transport and secretion are typically disrupted.