Abcam, ab241282, Anti-RPS28 antibody

Size: 100µg
Rabbit Polyclonal RPS28 antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human RPS28 aa 1 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human RPS28 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P62857

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab241282 was affinity purified using an epitope specific to RPS28 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RPS28 also known as ribosomal protein S28 is a component of the 40S subunit of the ribosome. The protein has a molecular mass of about 7.6 kDa and is part of the S28E family of ribosomal proteins. RPS28 is highly expressed in various tissues reflecting its importance in cells that are actively synthesizing proteins. This protein plays a mechanical role in ribosome function by participating in the assembly of ribosomal structures and facilitating translation.
Biological function summary
Ribosomal proteins like RPS28 are essential for protein biosynthesis. RPS28 is a part of the ribosomal small subunit complex which helps decode messenger RNA (mRNA) into polypeptides. Proper functioning of the ribosome ensures the accurate translation of genetic material into proteins which is necessary for cell growth and maintenance. The protein cooperates with other ribosomal proteins to maintain the integrity and functionality of the ribosomal machinery.
Pathways
RPS28 is involved in the translation pathway which is critical for gene expression. It contributes to the initiation phase of translation working alongside the eukaryotic initiation factor 3 (eIF3) complex. The protein also plays a role in the maturation of ribosomal RNA (rRNA) within the ribosome biogenesis pathway. Through these pathways RPS28 interacts with other ribosomal proteins such as RPS15 and RPS23 which are essential for the assembly and function of the ribosome.
Mutations in RPS28 have been linked to Diamond-Blackfan anemia a rare genetic condition characterized by bone marrow failure and anemia. This disorder demonstrates the protein's importance in hematopoiesis and red blood cell production. Additionally researchers are examining connections between RPS28 and its interaction with the p53 pathway given p53's role in tumor suppression and the DNA damage response suggesting potential implications in certain cancers. Understanding these interactions may contribute to better insights into the molecular basis of these diseases and potential therapeutic approaches.