Abcam, ab241364, Anti-GAS2L3 antibody

Size: 100µg
Rabbit Polyclonal GAS2L3 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human GAS2L3 aa 1-50.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human GAS2L3 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.Q86XJ1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab241364 was affinity purified using an epitope specific to GAS2L3 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GAS2L3 also known as GAS2-like protein 3 is a cytoskeletal-associated protein with a molecular mass of approximately 71 kDa. It often cooperates with actin and microtubules to stabilize the cell structure. Expression of GAS2L3 occurs in many tissues but it finds higher levels in proliferative cells particularly during mitosis. It carries unique domains that allow connections between the cytoskeleton components influencing cell shape and dynamics.
Biological function summary
GAS2L3 influences cell cycle progression and mitotic spindle organization acting as a part of the cell division machinery. This protein interacts with other cell division cycle proteins that ensure accurate chromosome segregation. Its association with the Ndc80 complex assists in the proper attachment of chromosomes to spindle microtubules. Failures in its function could affect spindle integrity which may lead to errors in cell division.
Pathways
GAS2L3 is significant in the regulation of the cell cycle and the actin cytoskeleton pathway. It connects with regulatory proteins such as Cyclin-dependent kinases which are key players in cell cycle advancement. GAS2L3's interaction with actin-binding proteins like cortactin shows its involvement in actin remodeling processes. These pathways highlight the complex network controlled by GAS2L3 to maintain orderly cell division and stability.
GAS2L3 dysfunction associates with cancerous pathologies and cell proliferation-related disorders. Changes in its normal activity can contribute to malignancies due to erroneous mitotic segregation and genome instability. GAS2L3 interacts with proteins such as p53 a well-known tumor suppressor indicating its potential role in tumorigenic processes when aberrations occur. Understanding GAS2L3’s contributions to these conditions reveals potential therapeutic targets for maintaining genomic fidelity.