Abcam, ab241550, Anti-Bcl 7A antibody [15C]

Size: 100µg / 1mg
Mouse Recombinant Monoclonal Bcl 7A antibody. Suitable for IHC-P and reacts with Human samples.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:15C,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Want a custom formulation?
This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Bcl 7A also known as B-cell CLL/lymphoma 7 protein family member A plays a role in cell regulation. It is a protein with a mass of approximately 23 kDa. Bcl 7A is expressed in several tissues notably the immune system including B cells. This expression pattern suggests its function is significant in cellular processes related to this system.
Biological function summary
Bcl 7A plays a role in apoptosis regulation affecting cell survival and death. It is part of a multiprotein complex and collaborates with other Bcl family members to maintain balance between cell survival and programmed cell death. The protein is necessary for proper lymphocyte development contributing to the immune response.
Pathways
Bcl 7A functions in the Wnt signaling pathway which is important for various developmental processes and cancer pathways. Bcl 7A interacts with other proteins like β-catenin facilitating the modulation of transcription of Wnt target genes. The protein’s involvement in apoptosis influences pathways important for maintaining cellular homeostasis.
Altered Bcl 7A function is associated with non-Hodgkin's lymphoma and chronic lymphocytic leukemia. Its irregular expression or mutation can lead to uncontrolled cell growth representing a step in lymphomagenesis. Bcl 7A interacts with Bcl-xL another member of the Bcl family in these contexts impacting the progression of these disorders.