Abcam, ab241612, Anti-ZC3H11A antibody

Size: 100µL
Rabbit Polyclonal ZC3H11A antibody. Suitable for IHC-P, IP, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human ZC3H11A aa 700-750.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ZC3H11A aa 700-750. The exact immunogen used to generate this antibody is proprietary information.O75152

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Antibody was affinity purified using an epitope specific to ZC3H11A immobilized on solid support., Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZC3H11A also known as zinc finger CCCH-type containing 11A is a protein encoded by the ZC3H11A gene. With a molecular mass of approximately 97 kDa this protein can be found expressed in various tissues with elevated levels in the brain heart and liver. Mechanically ZC3H11A functions as an RNA-binding protein participating in interactions with mRNA molecules. It contains a zinc finger domain that facilitates its interactions with nucleic acids influencing RNA stability and processing.
Biological function summary
This protein has a role in regulating mRNA stability and nuclear export. It often acts as a part of the larger mRNA export complex which includes other proteins that facilitate the transport of mRNA from the nucleus to the cytoplasm. By participating in the control of gene expression at the post-transcriptional level ZC3H11A contributes to cellular homeostasis and response to stress stimuli.
Pathways
This protein functions in the mRNA processing and transport pathways. It interacts with TREX (Transcription/Export) complex components such as Aly/REF export factor (ALYREF) to ensure proper mRNA export from the nucleus. ZC3H11A also integrates into the post-transcriptional gene regulation pathway aligning with proteins like THOC1 and THOC5 ensuring the precise control of gene expression by managing RNA fate within the cell.
Mutations or dysregulation of the ZC3H11A protein have implications in neurodegenerative diseases particularly those affecting mRNA processing and transport. For instance aberrant function of this protein has been studied in the context of Alzheimer's disease where RNA transport misregulation plays a role. ZC3H11A's connection to the THOC complex which is important in RNA metabolism links it to oncology where altered mRNA export mechanisms can contribute to cancer progression.